Formulation and Evaluation of Microsponge Drug Delivery System Using Indomethacin

In the present study controlled release formulation of Indomethacin microsponges were prepared by using Eudragit RS 100, pH independent release retardant polymer and PVA, stabilizer or emulsifier. Microsponges were prepared by Quasi emulsion solvent diffusion method by changing drug polymer ratio (3:1, 4:1, 5:1) and process was optimized. Microsponges were evaluated by micromeritic properties, drug content, encapsulation efficiency, and particle size. Characterization of Indomethacin microsponges were done by FT-IR spectroscopy, Differential scanning calorimetry, X-ray diffractometry and Scanning electron microscopy for pure drug, polymer, physical mixture and formulation. In-vitro dissolution study indicated that the release of Indomethacin varied according to the concentration of matrix forming polymer. Therefore, Indomethacin microsponges prepared in thus study are promising as being more useful than conventional formulation in therapy.